По мочевой кислоте я наверное прочел рекордное кол-во публикаций на pubmed - в целом это нетоксичный метаболит(например не выводится с потом в отличие от того же креатинина), и играет роль про и анти оксиданта.
URIC ACID: THE OXIDANT–ANTIOXIDANT PARADOX
URIC ACID: THE OXIDANT–ANTIOXIDANT PARADOX
A Surprising Role for Uric Acid: The Inflammatory Malaria Response
A Surprising Role for Uric Acid: The Inflammatory Malaria Response
Uric acid is an important contributor to inflammatory cytokine secretion, dendritic cell and T cell responses induced by Plasmodium
Uric acid, despite
being a major antioxidant in the human plasma, both correlates and predicts development of obesity, hypertension, and cardiovascular disease, conditions associated with oxidative stress. While one explanation for this paradox could be that a rise in uric acid represents an attempted protective response by the host, we review the evidence that uric acid may function either as an antioxidant (primarily in plasma) or pro-oxidant (primarily within the cell).
Sex-specific and Obesity-specific Association of Serum Uric Acid with Cognitive Function in Older Adults
Lower serum uric acid concentrations have been linked to cognitive dysfunction.
Uric acid is an antioxidant that accounts for over half of the free radical scavenging activity in humans.
Higher serum concentrations of uric acid have been associated with slower progression of several neurodegenerative diseases.
The relationship between serum levels of uric acid and prognosis of infection in critically ill patients
In case of severe infection, ischemia and hypoxemia of many organs activate xanthine oxidase in the capillary endothelium to act upon xanthine and hypoxanthine and convert them into uric acid.[22,25]
Thus uric acid production is increased.
It was proved that
hyperuricemia enhanced the production of pro-inflammatory mediators and in turn intensified the effect of endotoxin, which
resulted in further exacerbation of systemic inflammatory response. Also the variation of serum levels of uric acid in septic patients was in a pattern of decrease and then in a pattern of increase.
Оно неизбежно. Я видел и не такое в отчетах. Вроде прыжков креатинина до 10..15(от аб) с последующим отскоком. То же самое касается калия, мочевины и мочевой кислоты.