Елена Олеговна, прямо специально для Вас):
"We reexamine evidence and point to mainly
Russian studies ignored in English scientific literature that spirochete round bodies (RBs, also called coccoid bodies, globular bodies, spherical bodies, cysts, granules, L-forms, sphaeroplasts, or vesicles) are fully viable. RBs are spherical, membrane-bounded structures that appear in pure cultures as they age in proportion to the disappearance of helical forms. They tend to be immotile or less motile than typical helical-shaped spirochetes although they twitch and may move laterally. Analysis by thin section transmission electron microscopy (tsTEM) has revealed the presence of coiled protoplasmic cylinders and flagella inside RBs that lead investigators to hypothesize that they are pleiomorphic stages of spirochetes (
1) or that they are moribund. Anglophone medical discussion of spirochetoses (spirochete-associated infirmities, such as Lyme disease or syphilis) omit mention of “round bodies” or state that they have no clinical relevance (
2). Yet evidence abounds not only that RBs are viable but also that they may locomote, grow, and reproduce."
И еще много чего интересного
Destruction of spirochete Borrelia burgdorferi round-body propagules (RBs) by the antibiotic Tigecycline
http://www.pnas.org/content/106/44/18656.full
А также:
In vitro conversion ofBorrelia burgdorferi to cystic forms in spinal fluid, and transformation to mobile spirochetes by incubation in BSK-H medium
The purpose of this study was to examine the structural alterations of
Borrelia burgdorferi when exposed to spinal fluid. Normal, mobile spirochetes were inoculated into spinal fluid, and the spirochetes were converted to cysts (spheroplast L-forms) after 1–24 h. When these cystic forms were transferred to a rich BSK-H medium, the cysts were converted back to normal, mobile spirochetes after incubation for 9 to 17 days. The cultures were examined by dark field microscopy (DFM), interference contrast microscopy (ICM) and transmission electron microscopy (TEM). When neuroborreliosis is suspected, it is necessary to realize that
B. burgdorferi can be present in a cystic form, and these cysts have to be recognized by microscopy. This study may also explain why cultivation of spinal fluid often is negative with respect to
B. burgdorferi. Читать полностью
http://link.springer.com/article/10.1007/BF02771839
http://www.ncbi.nlm.nih.gov/pubmed/9646104