Одно "так дайте" чего стоит, требует еще... Вам тут никто не нанимался ссылки искать. Если вам интересно, то могли бы и сами это сделать.
Prolonged antibiotic therapy in PCR confirmed persistent Lyme disease
http://www.grin.com/en/e-book/16617...rapy-in-pcr-confirmed-persistent-lyme-disease
Wolfgang Klemann, MD, PhD
Bernt-Dieter Huismans, MD, PhD
Stephan Heyl, MD, PhD
Abstract: We examined a sample of 90 individuals that had previously received a
course of appropriate antibiotics for Lyme disease without experiencing full
resolution of their symptoms and had evidence of persistent infection documented
by PCR analysis.
Mean duration of symptoms was 9.5 years (range 1 - 40 years). The treatment
was adapted to the individual case according to clinical response. Long term
antibiotic therapy was initiated and patients were treated continuously for at
least 6 months, in some cases several years of intermittent therapy was administered.
About 38,8% of the patients experienced full remission of symptoms while about
56,7% reported a significant improvement, 5,6% of patients were deemed
refractory to therapy. Therapeutic modalities are discussed in detail.
Key words: persistent Lyme disease, Borrelia PCR, long term antibiotic
treatment, lyme serology, Borrelia DNA
Key issues:
·
All study patients were Borrelia- DNA positive
·
Commonly reported symptoms included fatigue, muscolo- sceletal and
neuro-psychiatric complaints
·
Only about 42% of patients had a history of an erythema migrans
·
Serologic testing is fairly insensitive in late disseminated lyme disease
·
Antibiotic treatment must be tailored to the individual clinical response in
late disseminated lyme disease
·
The majority of patients benefited from long term antibiotic treatment
·
Recurrence of symptoms was common during treatment
·
Long term antibiotic therapy was generally well tolerated
