4 Months rifampin (4RIF)
An overlooked finding in the same study of treatment of latent LTBI in mice was that rifampin alone for 2 months was equally efficacious as 2RZ, or 2 months of rifampin plus- INH
26. Complete bacteriologic clearing had occurred in all TB infected mice by the end of two months mono-RIF therapy. Unfortunately, despite this very promising evidence, only one randomized trial has evaluated a regimen of rifampin alone. In this trial, older men living in Hong Kong, who had pulmonary silicosis with a positive TST were randomized to placebo, 6INH, 3 months INH plus Rifampin, or 3 months Rifampin alone
30. During five years of follow up, 27 per cent of those randomized to placebo developed active TB, compared to 16, 13, and 10 per cent for the three regimens respectively. The estimated effectiveness of 3 months rifampin was approximately 65 per cent; this was better than the other regimens although the differences between active regimens was not significant, and all were significantly better than placebo
30. To date, there are no other published trial evaluating mono-RIF therapy. However, a large scale trial comparing the effectiveness and efficacy of 4RIF and 9INH is ongoing.
Several studies have reported that completion rates with 4RIF are substantially and significantly better than with 9INH
31–
34. In addition, rates of serious adverse events with 4RIF are very low, particularly rates of hepatotoxicity
31. In a recently published randomized trial rates of grade 3 to 4 adverse events were significantly lower with 4RIF than 9INH. Grade 3-4 hepatotoxicity occurred in 4 per cent of patients taking 9INH compared to less than 1 per cent in those taking 4RIF
34. The earlier results in the Hong Kong silicosis trial suggest that 4RIF should have efficacy of at least 65 per cent
30- equivalent to the documented efficacy of 6INH.
In summary, 4RIF appears to be well tolerated, has excellent completion and a very good safety record. However, 4RIF cannot be recommended for routine use until the results of the efficacy trial are available.
Кстати доксициклин тоже имеет некоторою активность против туберкулеза, так что если лечится риф+докси, то есть шанс и туберкулез латентный по ходу победить
Правда толку, снова заразят )