ну нет у меня инфекций, 30 000 USD ушло на операцию и прочее, прочее, прочее
Операция мне помогла, до операции у меня, вообще, не было самостоятельного стула.
тучные клетки содержат массу медиаторов воспаления..
LAna, вы не понимаете патогенез заболевания..
я не буду больше писать пока
Pathogenesis
Mutations in kinases (particularly in the tyrosine kinase Kit) and in enzymes and receptors (JAK2, PDGFRα, RASGRP4, Src-kinases, c-Cbl-encoded E3 ligase, histamine H4 receptor) which are crucially involved in the regulation of mast cell activity have been identified as necessary to establish a clonal mast cell population, but other abnormalities yet to be determined must be added for the development of a clinically symptomatic disease ([
7,
8,
25,
26]; further references therein). The observations that the same KIT mutation (e.g. D816V) can be associated with both good prognosis as well as progression to advanced disease [
27] and that the D816V mutation has also been detected in healthy subjects [
28] highlight the potential role of other factors in determining the progression/outcome of the disease. Recent findings suggest that the immunohistochemical and morphological alterations which constitute the WHO criteria for SM (formation of mast cell clusters; spindle-shaped morphology of mast cells; expression of CD25 on mast cells; Table
2) are causally related to and specific for the occurrence of a mutation in codon 816 of tyrosine kinase Kit in the affected mast cells [
6,
29,
30,
31]. Another aspect that limits the diagnostic value of this mutation is that during progression of SM the Kit mutant D816V may disappear ([
32]; own unpublished observation). Taken together, the recent genetic findings suggest that the clinically different subtypes of MCAD (encompassing SM, MCL, and MCAS) should be more accurately regarded as varying presentations of a common generic root process of mast cell dysfunction than as distinct diseases [
4,
7,
8,
11].
Некоторые из этих мутаций рецепторов находят при интерстициальном цистите,я на пабмеде нашла
Что запускает эти мутации непонятно...
Изменить свои гены мы можем только посредством генной инженерии, но она пока не дошла до таких заболеваний.