Болезнь Лайма: скрытая эпидемия

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Article:
Lyme Disease: The Hidden Epidemic
Raphael B. Stricker, M.D.
Vice President, International Lyme & Associated Diseases Society (ILADS)
House Committee on Foreign Affairs, Subcommittee on Africa, Global Health, and Human Rights


July 17, 2012

Summary


Lyme disease has reached epidemic proportions around the world. Recent animal and human
studies have confirmed the potential for persistent infection with the corkscrew-shaped Lyme
spirochete, Borrelia burgdorferi, as well as the complicating role of tick-borne coinfections
associated with failure of short-course antibiotic therapy. Furthermore, renewed interest in the role
of cell wall deficient (CWD) forms in chronic bacterial infection and progress in understanding the
molecular mechanisms of biofilms has focused attention on these processes in chronic Lyme
disease. Recognition of the importance of CWD forms and biofilms in tick-borne illness should
stimulate pharmaceutical research into new antimicrobial agents that target these mechanisms of
chronic infection with the Lyme spirochete. Concurrent clinical implementation of novel culture
techniques and proteomic screening offers a chance to correct significant worldwide deficiencies
in Lyme testing. Advances in these areas have the potential to revolutionize the diagnosis and
treatment of Lyme disease in the future.


http://archives.republicans.foreignaffairs.house.gov/112/HHRG-112-FA16-WState-StrickerR-20120717.pdf
 

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Говорит др. Горовитц:
Болезнь Лайма - эпидемия номер один в мире


 

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Dr. Richard Horowitz:

«This review article on Chronic Lyme disease in the International Journal of Family Medicine was just released. It gives a good overview of the complexity of borrelia infections, poor sensitivity of testing, persistence, role of co-infections and the need for Family physicians to work within a multidimensional chronic disease construct to help patients suffering from CLD. The MSIDS model discussed in my book is such a multidimensional construct, and the Lyme-MSIDS questionnaire can help physicians in different sub specialties screen for Lyme as a multi systemic illness. The scientific research discussed in this article, as well as the hundreds of peer reviewed scientific references referenced in my book and in the recently published ILADS guidelines, should allow those in charge of our health care system to become better informed. Lyme disease is the most common vector-borne disease in the US and Europe, and is a rapidly spreading global health threat. We need to carefully to listen to science, bound by compassion for sick and suffering patients, in order to find logical and cost effective solutions for this emerging epidemic.»
16-12-2014


Relevance of Chronic Lyme Disease to Family Medicine as a Complex Multidimensional Chronic Disease Construct: A Systematic Review



Liesbeth Borgermans,1Geert Goderis,2Jan Vandevoorde,1 and Dirk Devroey1

1Department of Family Medicine & Chronic Care, Vrije Universiteit Brussel (VUB), Laarbeeklaan 103, 1090 Brussels, Belgium2Department of General Practice and University Hospitals Leuven, Katholieke Universiteit Leuven (KUL), Kapucijnenvoer 33, 3000 Leuven, Belgium

Received 11 July 2014; Accepted 12 November 2014; Published 24 November 2014

Academic Editor: Christos D. Lionis

Copyright © 2014 Liesbeth Borgermans et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Abstract

Lyme disease has become a global public health problem and a prototype of an emerging infection. Both treatment-refractory infection and symptoms that are related to Borrelia burgdorferi infection remain subject to controversy. Because of the absence of solid evidence on prevalence, causes, diagnostic criteria, tools and treatment options, the role of autoimmunity to residual or persisting antigens, and the role of a toxin or other bacterial-associated products that are responsible for the symptoms and signs, chronic Lyme disease (CLD) remains a relatively poorly understood chronic disease construct. The role and performance of family medicine in the detection, integrative treatment, and follow-up of CLD are not well studied either. The purpose of this paper is to describe insights into the complexity of CLD as a multidimensional chronic disease construct and its relevance to family medicine by means of a systematic literature review.

http://www.hindawi.com/journals/ijfm/2014/138016/
 
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