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Inflammatory brain changes in Lyme borreliosis 2016-11-26

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Дата публикации
25 July 1996
J. Oksi, H. Kalimo, R. J. Marttila, M. Marjamaki, P. Sonninen, J. Nikoskelainen1 and M. K. Viljanen
Despite a rapid increase in the number of patients with
Lyme neuroborreliosis (LNB), its neuropathological aspects are poorly understood. The objective of this studv was evaluation of neuropathological, microbiological, and magnetic resonance imaging (MRI) findings in three patients with the Borrelia burgdorferi infection and neurological disease from whom brain tissue specimens were available. Perivascular or vasculitic lymphocytic inflammation was detected in all specimens. Large areas of demyelination in periventricular white matter were detected histologically and by MRI in one patient. The disease had a fatal outcome in this patient. Brain MRI suggested malignancies in two patients before histopathological studies were carried out.
One of these two patients was a child with sudden hemiparesis.

Another was a 40-year-old man presenting with epileptic seizures and MRI-detected multifocal lesions, which disappeared after repeated courses of antibiotics. We conclude that cerebral lymphocytic vasculitis and multifocal encephalitis may be associated with B. burgdorferi infection. The presence of B. burgdorferi DNA in tissue samples

from areas with inflammatory clianges indicates that direct invasion ofB. burgdorferi may be the pathogenetic mechanism for focal encephalitis in LNB.

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